In their seminal work, Hanahan and Weinberg outlined the hallmarks of cancer, which have been fundamental in our understanding of cancer's common traits and in rational drug design. This course will cover both classical and contemporary studies that have contributed to our understanding of these hallmarks. Topics covered in class will revolve around the 10 hallmarks of cancer, including sustained proliferative signals, evasion of growth suppressors, cellular immortalization, genome instability and mutation, avoiding immune destruction, resisting cell death, promoting tumor inflammation, metastasis, angiogenesis, and metabolic stress.