The field of Neuromodulation and its therapeutic application is experiencing unprecedented growth. Advanced therapies resulting from the convergence of machine learning, optical interfaces, electronics, mathematics, material sciences, image-guided surgery, neuroscience, and big data analyses are being rapidly developed and deployed. The primary goal of this course is to introduce students to various neuromodulation modalities, provide students with the knowledge to be prepared for research or industrial endeavors in neuromodulation as well as provide hands-on experience performing real brain data analyses. Topics covered include interventions that are non-invasive (i.e., transcranial stimulation, functional electrical stimulation, transcutaneous spinal cord stimulation), invasive (i.e., deep brain stimulation, subcutaneous spinal cord stimulation), emerging (i.e., focused ultrasound, laser interstitial thermal therapy), and pre-clinical (i.e., optogenetics, gene therapy), in the context of movement, psychiatric, pain, and memory disorders.