This is a multidisciplinary course that provides the necessary components, concepts and frameworks of sustainability and its relation to engineering projects. It introduces the basic ideas of systems thinking that are used to understand and model complex problems, such as input, output, control, feedback, boundary, and hierarchy. It then describes sustainability as a complex challenge of interacting technical, social, economic and environmental systems, and introduces systemic sustainability frameworks such as The Natural Step. It then focuses on the sustainability of organizations and the standards (e.g., ISO 26000 and GRI) that can help design effective sustainability improvement initiatives and strategies. A primary focus of the course is on life cycle assessment (LCA) and related standards (ISO14044, ISO14025) as a tool to understand the broad impacts of engineering projects, unit processes, products and services and the inevitable trade-offs in design decisions. Specific process case studies are examined related to chemical engineering and their relation to promoting a circular economy, including recycling of energy and material flows. Finally, the course presents the economic aspect of sustainability and how to create the business case to secure the support of decision makers in the implementation of sustainable processes in organizations.