This course presents an introduction to epidemiologic concepts and the application of quantitative methods. Topics include measurement of disease occurrence, descriptive epidemiology, ecologic studies, cohort studies, case-control studies, measurement validity, screening, causation, random variation, bias, confounding, effect modification, randomized controlled trials, and epidemic investigation. The course utilizes a wide variety of case studies from both chronic and infectious disease epidemiology, representing both landmark studies and newer research.