This course covers in-depth examination of bacterial peptidoglycan biosynthesis, how the mechanisms of the enzymes involved were determined and how these enzymes have been targeted for antibiotic discovery. At the end of the course, students will be able to apply chemical knowledge to understand, evaluate and speculate on how small molecules may interact with and affect biochemical pathways and enzyme systems. Using interpretation of biochemical assay results students will be able to propose hypothesis concerning the mechanisms of the enzymes involved and how they relate to the overall biochemical pathway.