An introduction to single crystal X-ray crystallography as a method of determining the structure of small molecules. The principal theme will be a description of the X-ray experiment from obtaining the crystal through to publishing the final structure. The objective of the course is to give students a working knowledge of the single crystal X-ray experiment. This will allow students to become more involved in the X-ray experiment and to read the crystallographic literature intelligently. Introduction to Crystals and Symmetry. Space groups (Triclinic, P2, P21, C2, Pc,P21/c, orthorhombic, tetragonal, others). Miller Indices, Reciprocal Lattices, and Diffraction. Intensity of Scattered X-rays, Data Acquisition, Data Reduction, and Structure Factors. Structure Solution, Structure Refinement, Evaluation of a Crystal Structure. Reference text: Structure Determination by X-ray Crystallography , M.F.C. Ladd and R.A. Palmer, Plenum Press.