In this course, graduate students will learn about why certain biomolecules make better drug targets than others and different strategies towards developing a cure for diseases. We will survey the function of a biomolecule in its systemic and cell biology context followed by a discussion on the mode of action of a drug on a molecular level. Topics will include small molecule inhibitors against aminoacyl-tRNA synthetases, proteasome inhibitors, PROTACs, RNA therapeutics, and antibodies. The course will include the discussion of methods used to assay the activity of enzymes and biological model systems as well as target identification. In addition to lectures, coffee chats with industry representatives and academic researchers associated with the topics discussed in the course will be offered. Presentations and the compilation of a mini review will give students the chance to practise skills that will aid them to succeed in their graduate degree.