The course is aimed at providing an up-to-date review of the pharmacological principles and therapeutic management of clinical conditions relevant to the practice of dentistry. This course emphasizes the need to apply a multidisciplinary approach to systemic pathologies and relevance for oral health. Topics include pain management, antimicrobials, respiratory, cardiovascular, central nervous system, anticoagulants, immunocompromised patients, antineoplastics, oral cancer, and use of computer drug databases in patient management. Students have an opportunity to work in small groups and present clinical cases of patients with complex systemic and oral pathologies.