A lecture and seminar course with assigned reading which will review the developments occurring in the field of biomaterials, as they relate to clinical dentistry. The course material is presented in four modules: 1) Material Structure and Technologies, reviewing metals, polymeric, and ceramic biomaterials; 2) Biomaterial-Biological Interfaces, reviewing advances in the study of Material/Biological Interfaces as they relate to protein, enzyme and cell interactions with biomaterials, as well as investigations examining the physical and chemical interactions of biomaterials with whole tissues; and 3) Bacteria Biomaterials and Host Interactions, including clinical applications and associated biomaterial issues (including material testing, failures, and drug delivery) in all the dental specialties 4) Elements of Tissue Engineering, reviewing gingival tissue engineering, growth factors for tissue regeneration, and clinical application of bone engineering. Students will be assessed throughout the term based on three criteria; a) ability to identify clinical and/or scientific problems related to issues discussed in class; b) to propose viable approaches to study the problems; and c) to be able to convey these ideas using an analytical approach.