Osseointegration is a central tenant of current dental therapy — yet, not only is the concept poorly understood, but the terminology and dogma surrounding this vitally important concept confuses even the most engaged practitioners. This course discusses the concept of osseointegration from the perspective of bone biology. Bone is one of the many connective tissues; and to understand bone biology one has to have an understanding of connective tissue structure and function. Of course, to truly understand the interface a multidisciplinary approach is necessary to take into account both the material and biological variables. To address this subject matter, the course is centered around every student being able to identify and critically evaluate each of the connective tissues. We do this by spending considerable time studying the microscopic structure of connective tissues; recording observations; and sharing information between the group. While this is happening a series of spontaneous tutorials, generated predominantly as a function of student inquiry, guides the group towards a unique understanding of the biology of, and logic that drives, osseointegration. It transpires that osseointegration is a wound healing phenomenon that reflects many natural phenomena where a new equilibrium is established following a disruption of homeostasis. Recently, as a result of work undertaken at the U of T, it has become possible, for the first time, to objectively compare the osseointegration rate and ultimate strength of bone anchorage of differing implant designs. Neither prior knowledge of connective tissue biology, nor material surface design, is required; but an inquiring mind is essential.