How have Indigenous and other colonialized people created, taken up, critiqued, transformed and resisted technologies, data, and science? From digital games to laboratories, from genetic research to pollution, from statistics to plants, we will discuss the ways land and body sovereignties are at stake in technoscience. We will learn from the growing field of Indigenous science and technology studies that includes historical and other approaches, and then put this field in conversation with works from other decolonial traditions.