The course discusses a broad range of topics related to innovation and governance including i) technological change and its social and economic consequences, ii) the spatial effects, which result from this, and iii) necessities for innovation policies at different territorial levels. The seminar is divided into three main parts. The first part deals with conceptual foundations of innovation, and explores the connection between economic learning, knowledge creation and innovation processes. In the second part, innovation and governance are investigated in territorial context, ranging from national and subnational innovation systems to permanent and temporary clusters and varieties of capitalism. The third part of the course discusses aspects of transnational innovation processes and multilevel governance challenges.