This course presents an introduction to the science of biomaterials, focusing on polymeric biomaterials and biocompatibility. Topics include biomaterial surface analysis, hydrogel rheology and swelling, protein adsorption, cell adhesion and migration, and the foreign body response. Primary focus is on implantable biomaterials but some attention will be given to applications of biomaterials in biotechnology and drug delivery. Specific device or other examples as well as the research literature will be used to illustrate the topic at hand.