This course explores the regulation of skeletal muscle energy metabolism during exercise in humans. Focus will be placed on the regulation of carbohydrate and fat metabolism in response to acute and chronic exercise and the potential impact of factors such as nutrition, biological sex, training and inactivity. In addition, students will explore the metabolic dysregulation that occurs in obesity and type 2 diabetes and how exercise-induced changes in skeletal muscle metabolism can result in improved health at the whole-body and tissue-specific level.