This is an advanced, seminar-based course designed to provide an in-depth examination of the molecular and cellular mechanisms that contribute to malignant transformation. The objective of the course is to improve your analytical and critical thinking skills and to establish an understanding of the interplay of metabolism, epigenetics and tumorigenesis. Topics will include: include the role of chromatin regulatory mechanisms that impact tumor cancer stemness; moonlighting function of metabolic enzymes that reshape cancer cell status and modulate chromatin modifications, transcriptional activities and signal transduction; characterization of molecular links between obesity/diabetes and cancer progression and discussion of genome wide technologies yielding new insights towards cancer therapeutic intervention.