Scientific exposition, discourse, and ethics are fundamental principles to the conduct of responsible basic, translational, and clinical research. This course will use a combination of didactic lectures and interactive group discussion to explore key elements of these principles under the broad headings of: 1) Principles of Ethical Conduct and Protection of Research Subjects; 2) Scientific Fraud, Plagiarism and Data Misrepresentation — Flagrant and Unintended; 3) Privacy and Confidentiality in the Genome Era (Data Sharing/Validation/Clinical Translation); 4) Authorship Responsibility in the Spirit of Collaboration and Intellectual Property Protection; and 5) Equity, Diversity, and Inclusion in Science. The format of each lecture will be both didactic, with the lecturer discussing fundamental issues and principles relevant to the topic, and interactive with opportunity for open discussion of a foundational aspect of the subject being addressed in the lecture.