This module will cover a spectrum of topics in cell biology and biochemistry, including cell-to-cell communication, sensing of extracellular signals, surface receptors as signaling modalities, second messengers, modular architecture of proteins, post-translational modifications as instructive signals, intracellular signal transduction and signaling pathways, effectors of signaling pathways, protein stability and turnover. The module will also encompass a series of themes in cellular metabolism, including cellular energetics, nutrient transport and utilization, plasticity in metabolic networks, cellular metabolism in disease and the interface between cell signaling and cell metabolism. The use of model systems in the study of signaling and metabolism, as well as methodologies for cell signaling research will be discussed. The students should expect to get an advanced understanding of signaling networks and metabolic pathways and knowledge of means for their interrogation.