The tumour microenvironment (TME) is a complex entity in human cancers. It is constituted by multiple structural, cellular, and metabolic aberrations that arise during tumorigenesis. How cellular and molecular features of TME underlie tumour development and progression, as well as how these characteristics form the basis for new biomarkers and cancer therapies will be covered in this topic. The class will be split into groups of 2 students. The instructor will deliver a lecture, followed by presentations (15 minutes) delivered by selected student groups. The presentation will be based on a paper relevant to that week’s topic that has been provided at least one week ahead of the class. A set of instructions will also be provided to groups ahead of time. The non-presenting groups will actively participate in the review/criticism of these presented papers. There will be 3 rounds of presentations each week. There will also be an assignment due one week after getting assigned. Some lecturers will use a variation of the above format for class participation.