Materials can exhibit dramatically altered mechanical properties and physical mechanisms when they have characteristic dimensions that are confined to small length-scales of typically below approximately 100 nm. These size-scale effects in mechanics result from the enhanced role of surfaces and interfaces, defects and material variations, and quantum effects. Nanostructured materials which exhibit these size-scale effects often have extraordinary mechanical properties as compared to their macroscopic counterparts. This course is designed to provide an introduction to nanomechanics and size-scale mechanical phenomena exhibited by nanostructured materials, and provide a platform for future advanced studies in the areas of computational/experimental nanomechanics and nanostructured materials design and application. Topics include: an introduction to nanomechanics; atomic/molecular structure of materials and nanomaterials synthesis; limitations of continuum mechanics, nanomechanical testing techniques (AFM, nanoindentation, in situ SEM/TEM); atomistic modeling techniques (DFT, MD, Course-grained MD); size-scale strength, plasticity, and fracture; Hall-Petch strengthening, superplasticity; nanotribology, atomistic origins of friction, nanoscale wear; nano-bio-mechanics; mechanics of nanocomposites.