This two-term course brings all students to a common knowledge base and introduces advanced concepts including, but not limited to: 1) Major aspects of Mendelian inheritance and single-gene disorders; 2) Quantitative trait genetics; 3) Complex and polygenic disorders; 4) Epigenetics; 5) Pharmacogenomics and personalized medicine; 6) Cancer genetics. Students learn human genetics from the perspective of phenotype / clinical presentation toward genotype in addition to a focus on molecular genetics and underlying mechanisms of human disease. Class time includes working through clinical and diagnostic case studies, and students engage with world leaders in research and clinical work in each of the major topic nodes. This course includes an assessment of both individual and group work. This fundamental course provides a knowledge framework for the entire Medical Genomics program and introduces key concepts that will be examined in detail in subsequent courses.