Main streets, or principal retail corridors, serve as anchors of economic activity, social gathering, and cultural expression in Canada's cities and towns. Since the onset of the COVID-19 pandemic, some main streets have struggled to maintain their vitality. Why do some streets thrive while others falter? What is the role of the sectoral composition of businesses, local built form, transportation infrastructure, characteristics of the surrounding residential community, the capacity of local businesses to organize, and/or specific federal, provincial, and local policy interventions?