This course is meant to get a "hands-on experience" of Clinical Pharmacology applied to Epilepsy and First Seizure Presentations, which reflect the most frequent type of brain disorders. The participant will learn: the basic pathophysiological concept for treating seizure disorder in all stages (first seizure, new-onset epilepsy, refractory epilepsy); the range of medications available with their historical background and putative mechanism; the importance of individually tailored treatment; various frequent clinical scenarios and their impact on drug choice (pregnancy, elderly, bone health); emergency treatment of status epilepticus; the most important lessons we got from clinical trials.