This course is designed to provide students with a comprehensive understanding of the rapidly evolving field of nucleic acid-based therapies. The course will delve into the fundamental principles of nucleic acid biology and how these principles are harnessed in the design of innovative therapeutic strategies. We will begin with an exploration of the structure and function of nucleic acids, focusing on their role in cellular processes and the molecular mechanisms underlying gene expression. This foundational knowledge will set the stage for a detailed examination of various types of nucleic acid medicines, including antisense oligonucleotides, small interfering RNAs (siRNAs), and messenger RNAs (mRNAs). A significant portion of the course will be dedicated to mRNA therapies and vaccines, which have gained considerable attention due to their role in the global response to the COVID-19 pandemic.

Students will learn about the design principles of mRNA vaccines, their mechanism of action, and the challenges and opportunities associated with their development and deployment. In addition to lectures, the course will incorporate case studies, group discussions, and critical analysis of recent scientific literature, fostering a deeper understanding of the real-world applications and implications of nucleic acid medicines. By the end of the course, students will be equipped with the knowledge and skills to evaluate the potential of nucleic acid medicines in treating a variety of diseases and contribute to this exciting field of pharmaceutical sciences.