Are you fascinated by the intricate workings of the brain and curious about what happens when neural systems fail? This course offers an in-depth exploration of the cellular, molecular, and circuit-level mechanisms that underlie neurological disease. Designed for graduate students and senior undergraduate students interested in neurophysiology, this advanced course examines how disruptions in fundamental biological processes — such as protein homeostasis, synaptic signaling, immune activation, and gene regulation — can give rise to complex neural disorders. Through lectures delivered by leading researchers and clinician-scientists, students will explore how discoveries in basic neuroscience are shaping new approaches to understanding and treating neurological disease.