Temporomandibular disorders (TMD) are the most common form of chronic orofacial pain and the second most frequent musculoskeletal pain condition. The complex multifactorial etiology of TMD makes diagnosis and treatment challenging. This course integrates the latest evidence in basic and clinical sciences related to TMD, to improve knowledge on TMD etiology and mechanisms, differential diagnosis, and evidence-based management. The course will also address the socioeconomic burden of acute and chronic pain, in addition to their effects on the patient’s quality of life. The topics will be presented by various scholars, dental and medical specialists.