This course provides the academic basis of clinical medicine for residents in dental anaesthesia. Course content includes interpreting complete medical histories and physical examination findings; understanding systemic disease through the lens of anesthesia as a specialty, in particular diseases of the cardiovascular, respiratory, and endocrine systems; understanding the indications for and interpretations of laboratory studies and other techniques used in physical diagnosis and preoperative evaluation, and application of clinical data to formulation of anesthetic plans and clinical patient care. The course consists of 3 hours of problem-based learning seminars. An additional 2 hours of seminar time per week is available if needed to ensure adequate discussion of learning objectives. Resident exploration of their preferred learning styles and development of skills in self-directed learning, critical thinking, group discussion, and self/peer evaluation are integral to this course. DEN1074Y is a prerequisite for PGY-2 clinical experiences in Internal Medicine, Cardiology, and Respirology.