The course is organized as a series of clinical-pathological conferences and covers all forms of disease of the mouth. A case-based approach is used for teaching and learning. The material for study is derived from the Oral Pathology Diagnostic Service and the hospital pathology departments. Emphasis is placed on synthesizing clinical, radiographic, and histological data for a comprehensive evaluation of the case being discussed. Current cases of interest are studied and in addition the surgical pathology of all oral disease is covered in a systematic manner. Seminars are held weekly during the Fall and Winter sessions. Students have the opportunity to review the case histories, radiographs (if applicable), and virtual microscopic slides of the cases to be presented in the upcoming session, so they can be prepared to discuss the differential diagnosis and use the histologic findings to arrive at a diagnosis. Students from different specialty programs can engage in interdisciplinary collaboration for diagnosis and treatment of the cases. Controversies in treatment and topics that require further clinical research will be addressed.