The course is organized as a series of clinical-pathological conferences and covers all forms of disease of the mouth. A case-based approach is used for teaching and learning. The material for study is derived from the Oral Pathology Diagnostic Service and the hospital pathology departments. Emphasis is placed on synthesizing clinical, radiographic, and histological data for a comprehensive evaluation of the case being discussed. Current cases of interest are studied and in addition the surgical pathology of all oral disease is covered in a systematic manner. Seminars are held weekly during the Fall and Winter semesters. This course builds on the prerequisite courses DEN1311Y Oral Surgical Pathology and DEN1312Y Advanced Oral Surgical Pathology I. Students will analyze cases with complex clinical presentation or discordance between clinical and radiographic findings. There is opportunity to discuss the role of additional investigations such as immunohistochemical staining and molecular studies. Students will develop an approach to communicate with the clinician to recommend further clinical investigations for extra-oral lesions or underlying systemic diseases.