One of the ironies of globalization is that the forces that were supposed to make distance less relevant have concentrated innovative activity within regions. As a result, some of the most important policy and business decisions are made locally. This course explores how municipal actors can navigate the opportunities, and challenges, associated with globalization. After explaining why innovation is concentrated in cities, the course debates why some cities are more innovative than others. To this end, the course discusses the role of size, government policy, human capital, social capital, branding and other issues. Two additional questions frame the analysis. How can municipal actors, who lack the fiscal resources and regulatory tools of a nation-state, promote innovation? And if innovative activity is concentrated in a handful of large cities, what options are available to smaller communities? By the end of the course, students are expected to develop a strategy to promote innovation in Toronto (or another community).