Slavery has existed in many human societies throughout history. Beginning in the sixteenth century, European empires pioneered a new system of racial chattel slavery predicated on enslaving Native Americans and the transportation of enslaved African captives to plantation zones in the Americas. This course examines the history of slavery in British North America and the United States (c. 1619-1865). We will explore both the Atlantic and domestic slave trades; Indigenous and Atlantic slaveries; the codification of racial difference that accompanied slavery's expansion; gender and the reproduction; enslaved people's lives and politics; the economic history of slavery; the politics of slavery in the United States (1776-1865); and the destruction of chattel slavery during the Civil War (1861-65). We will conclude by taking up what Saidiya Hartman calls the afterlives of slavery in post-war American history.