This series of interactive seminars and workgroups will explore methodologies relevant to the translation of molecular discoveries into clinical studies, and vice versa, through examples in select disease areas. We will examine techniques and technologies for in vitro, in vivo and ex vivo modeling of disease, drug action, and drug disposition. Methodologies enabling the measurement of surrogate outcomes including biomarkers from blood samples and clinical imaging modalities will be explored. Students will learn how clinical trials and alternative sources of data including consortia databases and public health records can be used to evaluate the benefits and adverse consequences of pharmacological treatment. Both commonly applied statistical methods and novel/alternative approaches to data analysis will also be considered.