This course will introduce basic pharmacogenetics concepts and provide opportunity for hands-on practice with the tools used within the field. Through applying genetic concepts, students will use research protocols to: (i) clean genetic data, (ii) use statistical inference to analyze unobserved genotypes, (iii) identify variants of relevance for drug response or unwanted effects of drugs, and (iv) learn about other up-to-date tools/approaches for genetic studies, such as polygenic risk scores, gene/pathway analysis, imputation (to be defined or maybe vary across individual projects).

Guest scientists will provide examples of the successful use of pharmacogenetics in the field of personalized medicine (or colleagues with strong experience in specific methods can also give them a lecture about the method). Using NIH databanks, students will work on a given project as they learn methodology, with the goal of generating findings that they may publish at the end of the course.