Pharmacotherapy options for addition have evolved and grown in recent years with varying levels of evidence available for their effectiveness, limited uptake, and often unclear roles in relation to non-pharmacological treatment options. This course explores medication options for treating the clinical presentations associated with substance use, including substance use poisoning, withdrawal management, and substance use disorders. Discussion will focus on the pharmacological rationale for medication use, the strength of evidence for their effectiveness, their place in therapy, and approaches in the context of special populations and psychiatric comorbidities. Classes will include student facilitated appraisals of key research papers. Assignments focus on synthesizing the evidence for specific medications and types of substances. A fundamental knowledge of pharmacology is required, demonstrated by successful completions of an undergraduate or other graduate pharmacology course.