Clinical Epidemiology and Evidence-Based Care is a core course in the Faculty of Dentistry. Successful completion of this course is one of the program requirements for the graduate students seeking advanced training in a clinical specialty. This course will demonstrate the scientific basis for clinical decision-making in prognosis, causation, diagnosis, and therapy following the principles of evidence-based health care. Examples from the dental literature are used to illustrate the concepts and their practical application. The specific objectives of the course are: 1) to introduce principles of epidemiology as applied to clinical research; 2) to provide Clinical Specialty Graduate students with the fundamental scientific skills in clinical epidemiology to enable them to practice evidence-based dental care; 3) to provide the students with skills in answering questions using biomedical literature; 4) to provide students with the skills needed to critically appraise a biomedical research article.