This unique course involves a weekly two-hour lecture and a practicum component of four hours per week. Lectures focus on design issues in term one and analysis issues in term two. The practicum involves working on one or more PhD-level projects, under the direct supervision of a Division of Biostatistics faculty-appointed biostatistician. Analysis of data and interpretation of results are emphasized. Student evaluation is based on end-of-term presentations, progress in the practicum component, and an end-of-year final report.