The Modern Evolutionary Synthesis is the current orthodox theory of evolution. It arose early in the 20th century through an amalgamation of Darwin's theory of natural selection and Mendel's theory of inheritance. It is now coming up for a century of unprecedented success. (The first serious intimation of a synthesis was produced by Fisher in 1918). Recently, however, the Modern Evolutionary Synthesis has begun to receive a battery of challenges. These arise mostly from empirical work in development, inheritance, the evolution of novelties inter alia. The challenges have provoked biologists, historians, and philosophers to re-evaluate the Modern Evolutionary Synthesis, to investigate its conceptual foundations, to explore its possible limitations. Increasingly calls for an extensive revision, expansion, or wholesale rejection of the Modern Evolutionary Synthesis — as well as systematic defences of the Synthesis — are being heard. The objective of this seminar series is to investigate the Modern Evolutionary Synthesis, its formulation, its conceptual foundations, the empirical and conceptual challenges it faces, and its prospects for survival or revision.