Understanding how different materials fail is a key design consideration in materials science. In this course students will be exposed to the mechanisms leading to the damage and failure of engineering materials, and modeling of failure at atomic and continuum levels. First, we will describe different mechanisms by which various materials fail, including metals, alloys, ceramics, composite materials, and nanomaterials; and the nature of failure — brittle vs. ductile. Then, various approaches to model and analyze damage and failure in materials will be discussed, including finite element-based failure analysis at the macroscale, and molecular dynamics at the atomic scale. Hands-on practice will be provided through practical case studies using softwares. Finally, students will apply these skills through a term project on a materials science problem of their interest.