To provide graduate students with a broad exposure to a range of current research areas related to ion channels. Critical advances and papers dealing with ion channel structure and function will be covered. For example, activation gating of cation channels, inactivation mechanisms in cation channels, mechanisms of ion permeation and selectivity in cation channels, modulation of expression and function by accessory subunits in cation channels, permeation and regulation of water channels, allosteric regulation of cation channels (by ions, lipids, and phosphorylation), chloride channel regulation, and mathematical and computer modeling of ion channels.