This weekly two-year seminar series (comprised of DEN5021Y and DEN50222Y) reviews the historic and principle literature that provides the basis for understanding of endodontic disease and its treatment. The scientific literature identified as being important to the field is critically reviewed and key concepts are established. Specific areas reviewed include the (i) development, structure, and pathophysiology of the dental pulp and periapical tissues, (ii) causes, prevention, and management of endodontic post-treatment disease (treatment failure), (iii) effects and management of traumatic injury to the developing and developed permanent dentition, (iv) evolution and testing of methods and materials for root canal preparation and filling, (v) long-term outcomes of endodontic treatment, (vi) considerations for post-treatment restoration, (vii) benefits and risks associated with internal bleaching, and (viii) several clinical topics. An extensive reading list and the oral presentation of selected articles on assigned topics constitute the course requirement. The series is a continuum spanning two years. Students enter the course in the beginning or in the middle in alternating years.