Are you fascinated by the intricate workings of the brain and curious about what happens when neural systems fail? PSL1446H offers an in-depth exploration of the cellular, molecular, and circuit-level mechanisms that underlie neurological disease. Designed for graduate students and senior undergraduate students interested in neurophysiology, this advanced course examines how disruptions in fundamental biological processes — such as protein homeostasis, synaptic signaling, immune activation, and gene regulation — can give rise to complex neural disorders. Through lectures delivered by leading researchers and clinician-scientists, students will explore how discoveries in basic neuroscience are shaping new approaches to understanding and treating neurological disease.

The course is organized around three major themes: (i) Neurodegenerative and Neuroinflammatory Disorders; (ii) Genetic and Developmental Disorders; and (iii) Neural Injury and Repair. Across these themes, JNS1446H integrates perspectives from molecular neuroscience, systems physiology, and clinical research. A recurring thread throughout the course is the advancement of precision medicine, highlighting how emerging technologies — from genome editing to circuit-level interrogation — are transforming how neural disorders are studied and treated.

Through interactive lectures, primary literature, and case-based discussion, students will develop a deeper understanding of how fundamental discoveries in neuroscience translate into new therapeutic strategies for brain disorders.