Pharmacology and Toxicology

Pharmacology and Toxicology: Introduction

​​​​​​​​​​​​​​​​​​​​​​​​​​Faculty Affiliation

Medicine

Degree Programs

Pharmacology

MSc​
Field:
Applied Clinical Pharmacology​
PhD
 

Combined Degree Programs

Collaborative Specializations

The following collaborative specializations are available to students in participating degree programs as listed​ below:

  1. Addiction Studies
    • Pharmacology, MSc, PhD
  2. Biomedical Toxicology
    • Pharmacology, MSc, PhD
  3. Cardiovascular Sciences
    • Pharmacology, MSc, PhD
  4. Human Development
    • Pharmacology, ​PhD
  5. Neuroscience
    • Pharmacology, MSc, PhD
  6. Resuscitation Sciences
    • Pharmacology, MSc, PhD
  7. Women's Health
    • Pharmacology, MSc, PhD

Overview

Faculty in the Department of Pharmacology and Toxicology conduct research in the following areas:

  • biochemical and molecular pharmacology

  • cardiovascular pharmacology

  • clinical pharmacology

  • drug addiction

  • drug metabolism, distribution, and pharmacokinetics

  • endocrine pharmacology

  • immunopharmacology

  • neuropharmacology

  • pharmacogenetics

  • psychopharmacology

  • receptor pharmacology

  • second messengers and signal transduction

  • toxicology

Contact and Address

Web: www.pharmtox.utoronto.ca
Email: pharmtox.dept@utoronto.ca
Telephone: (416) 978-5244
Fax: (416) 978-6395

Department of Pharmacology and Toxicology
University of Toronto
Room 4207, Medical Sciences Building
Toronto, Ontario M5S 1A8
Canada

Pharmacology and Toxicology: Graduate Faculty

Full Members

Al-awar, Rima - PhD
Beaulieu, Martin - PhD
Brands, Bruna - PhD
Dorian, Paul - MSc, MDCH
George Bahl, Susan - MD
Goldstein, Benjamin - MD
Grant, Denis - BSc, PhD
Grupp, Larry - DSc
Hampson, David - PhD
Ito, Shinya - MD, BM
Kish, Stephen John - BSc, MSc, PhD
Lanctot, Krista - MSc, PhD
Laposa, Rebecca - PhD
Le Foll, Bernard - MSc, DrMed, PhD
Le, Dzung - PhD
Matthews, Jason - PhD
McPherson, J. Peter - MSc, PhD (Coordinator of Graduate Studies)
Meyer, Jeffrey - MD
Mitchell, Jane - BSc, PhD
Mizrahi, Romina - MD, PhD
Moore, Malcolm - MD
Nobrega, Jose - PhD
O'dowd, Brian - PhD
Pang, K Sandy - BSc, PhD
Parker, John - BA, MD
Petronis, Arturas - MD
Piquette-Miller, Micheline - BScPhm, PhD
Pollock, Bruce - BSc, MD, PhD
Ramsey, Amy - PhD
Riddick, David - BSc, PhD
Ross, Ruth Alexandra - PhD (Chair and Graduate Chair)
Roy, Peter John - BSc, PhD
Salahpour, Ali - PhD
Salmena, Leonardo - PhD
Schimmer, Bernard - BS, PhD
Sibille, Etienne - BSc, PhD
Snead III, Carter - BS, MD, MD
Tyndale, Rachel - PhD
Uetrecht, Jack - BSc, MSc, MD, PhD
Verma, Subodh - MSc, MD, PhD
Warsh, Jerry - MD
Wells, James - BSc, MSc, PhD
Wells, Peter - BScPhm, DP
Wong, Albert - MD, PhD
Young, Lionel Trevor - MSc, MD, PhD
Zawertailo, Laurie Anne - PhD

Members Emeriti

Burnham, Willets - PhD
Endrenyi, Laszlo - PhD
Heersche, Johannes - BSc, PhD
Inaba, Tadanobu - BEng, MSc, PhD
Kadar, Dezso - BSc, MSc, PhD
Kalant, Harold - BSc, MD, PhD
O'Brien, Peter John - BSc, MSc, PhD
Okey, Allan - BSc, MSc, PhD
Pace-Asciak, Cecil - PhD
Seeman, Philip - BSc, MSc, MDCH, PhD
Sellers, Edward - MD, PhD

Associate Members

Andreazza, Ana Cristina - BPhm, MSc, PhD, PhD
Arnot, Michelle - PhD
Boutros, Paul - PhD
Kotsopoulos, Joanne - BSc, MSc, PhD
Nulman, Irena - MD
Park, Hee-Won - DVSM, MSc, DChem
Sun, Hong-Shuo - MSc, DrMed, DPhil
Swardfager, Walter - PhD
Woodland, Cindy - PhD
Zack, Martin - BSc, MASc, PhD

Pharmacology and Toxicology: Pharmacology MSc (Thesis-Based Option)

Master of Science​

Program Description

In the MSc program, students are expected to undertake self-directed study and demonstrate proficiency in pharmacological principles throughout the course of the program. They are able to engage in one of two formats of study: 1) thesis-based study or 2) course-based study in the field of Applied Clinical Pharmacology.

In the thesis-based study, students are expected to think critically about scientific issues and develop a knowledge base in pharmacology while formulating hypotheses in a specific area of pharmacological research. They will test their hypotheses through active research and present their investigations in a thesis. 

In the course-based Applied Clinical Pharmacology field, students will engage in research and hands-on training in academic, commercial, health care, and government settings. Courses will feature a breadth of fundamental and applied pharmacology topics with emphasis on translational research.

The MSc program can be taken on a full-time or part-time basis.

 

MSc Program (Thesis-Based Option)

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Pharmacology and Toxicology's additional admission requirements stated below.

  • Appropriate bachelor's degree from a recognized university with a final-year average of at least a B+.

  • Applicants are normally required to have taken courses in physiology, biochemistry, or applied sciences sufficient to form a foundation for their work in pharmacology.

  • All successful applicants are responsible for obtaining research supervision and financial support before they are permitted to officially register in their program.

Program Requirements

  • Coursework. Students must complete PCL 1002Y Graduate Pharmacology (1.0 full-course equivalent [FCE]). The academic program may require additional coursework.

  • Each student will present a departmental seminar after approximately one year in the program.

  • Each student will participate in a research program and present the results of the investigation as a written thesis. The thesis will be evaluated and defended to the satisfaction of a thesis examination committee.

  • MSc students in pharmacology who intend to continue their studies in the PhD program may choose to be evaluated during their MSc oral defence.

  • Minimum period of one full year of residence, during which time the student is required to be on campus full-time and consequently in such geographical proximity as to be able to participate fully in the department's activities associated with the program.

Program Length

6 sessions full-time (typical registration sequence: F/W/S/F/W/S);
9 sessions part-time

Time Limit

3 years full-time;
6 years part-time

Pharmacology and Toxicology: Pharmacology MSc, Applied Clinical Pharmacology Field

MSc Program (Course-Based Option)

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. App​licants must also satisfy the Department of Pharmacology and Toxicology’s additional admission requirements stated below.

  • An appropriate bachelor’s degree from a recognized university with a final-year average of at least a B+.

  • Applicants are normally required to have taken courses in physiology, biochemistry, or applied sciences sufficient to form a foundation for their work in pharmacology.

Program Requirements

Coursework. Students must complete 8.0 full-course equivalents (FCEs) as follows:

  • Year 1 (3.5 FCEs total):

    • PCL 1001Y Systems Pharmacology

    • PCL 1004Y Clinical Pharmacology

    • PCL 1402H Pharmacology and Toxicology in Drug Development

    • PCL 1491H Clinical Pharmacology: Principles in Practice

    • PCL 1100H Applied Skills in Clinical Pharmacology

  • Year 2 (3.5 FCEs total):

    • Required courses (1.5 FCEs):

      • PCL 1002Y Graduate Pharmacology

      • PCL 1101H Technology, Techniques, and Translation in Pharmacology and Toxicology

    Plus

    • Elective courses (2.0 FCEs) from the following list:

      • PCL 1012H Cognitive Neuropharmacology

      • PCL 1300H Selected Topics in Clinical Studies

      • PCL 2100H Practicum in Clinical Pharmacology

      • PCL 2101Y Practicum in Clinical Pharmacology

      • BTC 1830H Medical and Scientific Challenges in Marketing New Therapeutics

      • JFK 1120H Selected Topics in Drug Development I

      • JNP 1014Y Interdisciplinary Toxicology

      • JPM 1005Y Behavioural Pharmacology

      • LMP 1407H Introductory Biostatistics and Clinical Investigation or CHL 5201H Biostatistics for Epidemiologists

    Clinical practicums (either PCL 2100H or PCL 2101Y; credit/no credit), if chosen from electives, must be completed by Year 2.

  • Major Research Project (1.0 FCE).

    Students will enrol in PCL 2200Y0, normally in the Summer of Year 1 or no later than the Fall of Year 2.

Program Length

6 sessions full-time (typical registration sequence: F/W/S/F/W/S);
9 sessions part-time

Time Limit

​3 years full-time;
6 years part-time

0 Course that may continue over a program. The course is graded when completed.

 

MSc Program (Course-Based, Advanced-Standing Option)

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. App​licants must also satisfy the Department of Pharmacology and Toxicology’s additional admission requirements stated below.

  • An appropriate bachelor’s degree from a recognized university with a final-year average of at least a B+.

  • Applicants are normally required to have taken courses in physiology, biochemistry, or applied sciences sufficient to form a foundation for their work in pharmacology.

  • At the discretion of the program director, applicants may be considered for advanced standing with either:

    • a bachelor’s degree in pharmacology or biomedical toxicology or

    • MD degree (undergraduate medical education) with coursework in pharmacology.

Program Requirements

Coursework. Students must complete at least 4.0 full-course equivalents (FCEs) as follows:

  • PCL 1002Y Graduate Pharmacology (1.0 FCE)

  • PCL 1004Y Clinical Pharmacology (1.0 FCE)

  • PCL 1100H Applied Skills in Clinical Pharmacology (0.5 FCE)

  • At least one half-course elective (0.5 FCE) chosen from the following list, and upon recommendation of the program director:

    • PCL 1012H Cognitive Neuropharmacology

    • PCL 1300H Selected Topics in Clinical Studies

    • PCL 2100H Practicum in Clinical Pharmacology

    • PCL 2101Y Practicum in Clinical Pharmacology

    • BTC 1830H Medical and Scientific Challenges in Marketing New Therapeutics

    • JFK 1120H Selected Topics in Drug Development I

    • JNP 1014Y Interdisciplinary Toxicology

    • JPM 1005Y Behavioural Pharmacology

    • LMP 1407H Introductory Biostatistics and Clinical Investigation or CHL 5201H Biostatistics for Epidemiologists
  • PCL 2200Y0 Major Research Project (1.0 FCE), taken in the Fall of Year 1.

Program Length

3 sessions (typical registration sequence: F/W/S)

Time Limit

​3 years

0 Course that may continue over a program. The course is graded when completed.

Pharmacology and Toxicology: Pharmacology PhD

Doctor of Philosophy

Program Description

The objective of the PhD degree is to have students possess a comprehensive understanding of the general area of pharmacology, in addition to specific expertise in their particular area of interest. They build on their knowledge of pharmacology so that they are able to think critically about specific areas in pharmacology. They should be able to formulate and design, as well as carry out and interpret investigations. Their findings should be publishable. They should show capacity for continuing significant contributions in pharmacology and for conducting independent research.

Applicants may enter the PhD program via one of three routes: 1) following completion of an appropriate master’s degree; 2) transfer from the University of Toronto MSc program; or 3) direct entry following completion of an appropriate bachelor’s degree.

 

PhD Program

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Pharmacology and Toxicology's additional admission requirements stated below.

  • Appropriate master's degree from a recognized university with an average of at least a B+ in master's degree courses.

  • Applicants are normally required to have taken courses in physiology, biochemistry, or applied sciences sufficient to form a foundation for their work in pharmacology.

  • The department determines the eligibility of prospective students. The department assesses the student's ability for advanced study and independent research in ph​armacology.

  • Students transferring from the master's program in Pharmacology to the PhD program may receive full credit for master's courses towards doctoral course requirements, with the department's permission.

  • Well-qualified students with excellent research potential holding an appropriate bachelor's degree from a recognized university may be considered for direct entry to the PhD program. These applicants must have achieved a minimum final-year average of A-. 

  • Applicants admitted without prior screening (i.e., with MSc degrees from other departments or universities, and students admitted with a bachelor's degree) will have their research ability reviewed after completion of one year. Upon successful completion of a departmental seminar and recommendation from the student's advisory committee, the student will be permitted to proceed with the PhD program.

  • The department must be satisfied about the applicant's background, accomplishments, and financial support.

  • All successful applicants are responsible for obtaining research supervision and financial support before they are permitted to officially register in their program.

Program Requirements

  • Coursework. Students must complete 3.0 full-course equivalents (FCEs) as follows:

    • PCL 1002Y Graduate Pharmacology (primary subject)

    • PCL 1003YSeminars in Pharmacology (credit/no credit course)

    • 1.0 additional FCE (secondary subject) 

    • Any other courses advised by the Graduate Education Committee. The student's advisory committee should help the student determine the secondary course.

  • Pharmacology graduate faculty members also offer a variety of laboratory-based and tutorial-based learning modules to provide breadth to the student's training experience beyond their particular areas of research focus. During their program, PhD students are required to choose four breadth modules from among available options. 0.5 FCE from outside the student's research area may substitute for one of the five breadth modules. The student's advisory committee will assist the student in choosing suitable modules.

  • As part of the course requirement for PCL 1003Y0Seminars in Pharmacology, the student must present thesis material in seminars to the department on two occasions, one of which will take place between two and six months prior to the departmental Final Oral Examination.

  • Each student will participate in a research program and present the results of the investigation as a written thesis. The thesis must be orally defended to the satisfaction of a thesis examination committee.

  • Minimum period of two full years of residence, during which time the student is required to be on campus full-time and consequently in such geographical proximity as to be able to participate fully in the department's activities associated with the program.

Program Length

4 years full-time; 5 years transfer-from-master's; 5 years direct-entry

Time Limit

6 years full-time; 7 years transfer-from-master's; 7 years direct-entry

0 Course that may continue over a program. The course is graded when completed.

Pharmacology and Toxicology: Pharmacology MSc, MSc Applied Clinical Pharmacology Field, PhD Courses

The department should be consulted each session as to course offerings. Students may also find up-to-date course information on the departmental website.

​PCL 1001Y
Syst​ems Pharmacology​
​PCL 1002Y
​Graduate Pharmacology
​PCL 1003Y0
​Seminars in Pharmacology (Credit/No Credit)
​PCL 1004Y
​Clinical Pharmacology
​PCL 1012H
Cognitive Neuropharmacology​
​PCL 1101H
​Technology, Techniques, and Translation in Pharmacology and Toxicology
​PCL 1110H
​Applied Skills in Clinical Pharmacology
​PCL 1300H
Selected Topics in Clinical Pharmacology and Toxicology (Credit/No Credit) ​(prerequisite: PCL 1100H)
​PCL 1402H
​Pharmacology and ​Toxicology in Drug Development
​PCL 1491Y
​Clinical Pharmacology: Principles in Practice (co-requisite: PCL 1004Y or prior pharmacokinetics course)
PCL 2100H Practicum in Clinical Pharmacology (Credit/No Credit)
PCL 2101Y Practicum in Clinical Pharmacology (Credit/No Credit)
​​PCL 2101H0
​Practicum in Clinical Pharmacology I (Credit/No Credit) (prerequisite: PCL 1100H)
PCL 2102H0
​Practicum in Clinical Pharmacology II (Credit/No Credit) (prerequisite: PCL 1100H)
​PCL 2200Y0
Major Research P​roject (prerequisite or co-requisite: PCL 1100H) 
​PCL 2201Y0
​Research Project Extended Study (Credit/No Credit)​ (prerequisite: PCL 2200Y)
​JF​K 1120H
Selected Topics in Drug Development I​
​JFK 1121H
Selected Topics in Drug Development II​
​JFK 1122H
​Drug Transport Across Biological Membranes
​JNP 1014Y
​Interdisciplinary Toxicology
​JNP 1016H
​Graduate Seminar in Toxicology
​JNP 1017H+
​​Current Topics in Molecular and Biochemical Toxicology
​JNP 1018H+
Molecular and Biochemical Basis of Toxicology
​JNR 1444Y
​Fundamentals of Neuroscience: Cellular and Molecular
​JPM 1​005Y
​Behavioural Pharmacology
​JYG 1555H
​Advanced Topics: Cellular and Molecular Neurobiology

​0 Course that may continue over a program. The course is graded when completed.

+ Extended course. For academic reasons, coursework is extended into session following academic session in which course is offered.