Pharmacology and Toxicology

Pharmacology and Toxicology: Introduction

​​​​​​​​​​​​​​​​​​​​​​​​​​Faculty Affiliation

Medicine

Degree Programs

Pharmacology

MSc

  • Field:
    • Applied Clinical Pharmacology
 

PhD

Combined Degree Programs

Collaborative Specializations

The following collaborative specializations are available to students in participating degree programs as listed​ below:

Overview

Faculty in the Department of Pharmacology and Toxicology conduct research in the following areas:

  • biochemical and molecular pharmacology
  • cardiovascular pharmacology
  • clinical pharmacology
  • drug addiction
  • drug metabolism, distribution, and pharmacokinetics
  • endocrine pharmacology
  • immunopharmacology
  • neuropharmacology
  • pharmacogenetics
  • psychopharmacology
  • receptor pharmacology
  • second messengers and signal transduction
  • toxicology

Contact and Address

Web: www.pharmtox.utoronto.ca
Email: pharmtox.dept@utoronto.ca
Telephone: (416) 978-3851

Department of Pharmacology and Toxicology
University of Toronto
Medical Sciences Building, 1 King's College Circle, Room 4207
Toronto, Ontario M5S 1A8
Canada

Pharmacology and Toxicology: Graduate Faculty

Full Members

Al-awar, Rima - PhD
Andreazza, Ana Cristina - BPhm, MSc, PhD, PhD
Beaulieu, Martin - PhD
Brands, Bruna - PhD
Cherney, David - MD, PhD
Daskalakis, Jeff - MD
Dorian, Paul - MSc, MDCH
Eubanks, James - BSc, AA, PhD
George Bahl, Susan - MD
Goldstein, Benjamin - MD
Grant, Denis - BSc, PhD
Hampson, David - PhD
Ito, Shinya - MD, BM
Kish, Stephen John - BSc, MSc, PhD
Kotsopoulos, Joanne - BSc, MSc, PhD
Lanctot, Krista - MSc, PhD
Laposa, Rebecca - PhD
Le Foll, Bernard - MSc, DrMed, PhD
Le, Dzung - PhD
Matthews, Jason - PhD
McIntyre, Roger - MD
McPherson, J. Peter - MSc, PhD (Coordinator of Graduate Studies)
Meyer, Jeffrey - MD
Mitchell, Jane - BSc, PhD
Mizrahi, Romina - MD, PhD
Mueller, Daniel - MD
Nobrega, Jose - PhD
Pang, Sandy - BSc, PhD
Parker, John - BA, MD
Petronis, Arturas - MD
Piquette-Miller, Micheline - BScPhm, PhD
Pollock, Bruce - BSc, MD, PhD
Ramsey, Amy - PhD
Riddick, David - BSc, PhD
Ross, Ruth Alexandra - PhD (Chair and Graduate Chair)
Roy, Peter John - BSc, PhD
Rusjan, Pablo - PhD
Salahpour, Ali - PhD
Salmena, Leonardo - PhD
Schapira, Matthieu - MChem, PhD
Schimmer, Bernard - BS, PhD
Sibille, Etienne - BSc, PhD
Snead III, Carter - BS, MD, MD
Swardfager, Walter - PhD
Tyndale, Rachel - PhD
Uetrecht, Jack - BSc, MSc, MD, PhD
Verma, Subodh - MSc, MD, PhD
Wells, James - BSc, MSc, PhD
Wells, Peter - BScPhm, DP
Wong, Albert - MD, PhD
Woo, Minna - MD
Young, Trevor - MSc, MD, PhD
Zawertailo, Laurie Anne - PhD

Members Emeriti

Burnham, Willets - PhD
Endrenyi, Laszlo - PhD
Kalant, Harold - BSc, MD, PhD
Okey, Allan - BSc, MSc, PhD
Pace-Asciak, Cecil - PhD
Seeman, Philip - BSc, MSc, MDCH, PhD
Warsh, Jerry - MD

Associate Members

Arnot, Michelle - PhD
Banasr, Mounira - PhD
Di Ciano, Patricia - PhD
Hamadanizadeh, Anita - PhD
McIntyre, Roger - MD
Mittmann, Nicole - PhD
Sun, Hong-Shuo - MSc, DrMed, DPhil
Vedadi, Masoud - PhD
Woodland, Cindy - PhD
Zack, Martin - BSc, MASc, PhD

Pharmacology and Toxicology: Pharmacology MSc (Thesis-Based Option)

Master of Science​

Program Description

In the MSc program, students are expected to undertake self-directed study and demonstrate proficiency in pharmacological principles throughout the course of the program. They are able to engage in one of two formats of study: 1) thesis-based study or 2) course-based study in the field of Applied Clinical Pharmacology.

In the thesis-based study, students are expected to think critically about scientific issues and develop a knowledge base in pharmacology while formulating hypotheses in a specific area of pharmacological research. They will test their hypotheses through active research and present their investigations in a thesis.

In the course-based Applied Clinical Pharmacology field, students will engage in research and hands-on training in academic, commercial, health care, and/or government settings. Courses will feature a breadth of fundamental and applied pharmacology topics with emphasis on translational research.

The MSc program can be taken on a full-time or part-time basis.

MSc Program (Thesis-Based Option)

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Pharmacology and Toxicology's additional admission requirements stated below.

  • Appropriate bachelor's degree from a recognized university with a final-year average of at least a B+.

  • Applicants are normally required to have taken courses in physiology, biochemistry, or applied sciences sufficient to form a foundation for their work in pharmacology.

  • All successful applicants are responsible for obtaining research supervision and financial support before they are permitted to officially register in their program.

Program Requirements

  • Coursework. Students must complete PCL 1002Y Graduate Pharmacology (1.0 full-course equivalent [FCE]). The academic program may require additional coursework.

  • Each student will present a departmental seminar after approximately one year in the program.

  • Each student will participate in a research program and present the results of the investigation as a written thesis. The thesis will be evaluated and defended to the satisfaction of a thesis examination committee.

  • MSc students in pharmacology who intend to continue their studies in the PhD program may choose to be evaluated during their MSc oral defence.

  • Minimum period of one full year of residence, during which time the student is required to be on campus full-time and consequently in such geographical proximity as to be able to participate fully in the department's activities associated with the program.

Program Length

6 sessions full-time (typical registration sequence: F/W/S/F/W/S);
9 sessions part-time

Time Limit

3 years full-time;
6 years part-time

Pharmacology and Toxicology: Pharmacology MSc; Field: Applied Clinical Pharmacology

MSc Program: Applied Clinical Pharmacology Field (Course-Based Option)

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Pharmacology and Toxicology’s additional admission requirements stated below.

  • An appropriate bachelor’s degree from a recognized university with a final-year average of at least a B+.

  • Applicants are normally required to have taken courses in physiology and biochemistry, or applied sciences sufficient to form a foundation for their work in pharmacology.

Program Requirements

Coursework. Students must complete 8.0 full-course equivalents (FCEs). The curriculum is designed in an integrated fashion such that each subsequent course reinforces and builds upon prior knowledge. Students are expected to complete the required courses in Year 1. Elective courses may be taken in either year with practicum opportunities offered following successful completion of the required courses.

  • Year 1 required courses (6.0 FCEs); these courses are spread throughout the first 12 months of the program:

    • PCL 1001Y Systems Pharmacology

    • PCL 1002Y Graduate Pharmacology

    • PCL 1004Y Clinical Pharmacology

    • PCL 1100H0 Applied Skills in Clinical Pharmacology

    • PCL 1101H0 Technology, Techniques, and Translation in Pharmacology and Toxicology

    • PCL 1402H Pharmacology and Toxicology in Drug Development

    • PCL 1491H Clinical Pharmacology: Principles in Practice

    • PCL 2200Y0 Major Research Project.

Plus

  • Elective courses (2.0 FCEs). Elective coursework is selected through consultation with the program director with the intention to allow individual students to tailor their degree towards their interests and career goals. Popular elective courses include:

    • PCL 1300H Selected Topics in Clinical Pharmacology (Credit/No Credit)

    • PCL 2100Y0 Practicum in Clinical Pharmacology (Credit/No Credit; 2.0 FCEs)

    • PCL 2101Y0 Practicum in Clinical Pharmacology I (Credit/No Credit)

    • PCL 2102Y0 Practicum in Clinical Pharmacology II (Credit/No Credit)

    • PCL 2201Y0 Research Project Extended Study (Credit/No Credit)

    • APS 1001H Project Management

    • CHL 5201H Biostatistics I

    • JNP 1014Y Interdisciplinary Toxicology

    • JPM 1005Y Behavioural Pharmacology

    • RSM 2017H Pharmaceutical Strategy.

Program Length

6 sessions full-time (typical registration sequence: F/W/S/F/W/S);
9 sessions part-time

Time Limit

​3 years full-time;
6 years part-time

0 Course that may continue over a program. The course is graded when completed, or credit is given when the course is completed.

 

MSc Program: Applied Clinical Pharmacology Field (Course-Based, Advanced-Standing Option)

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Pharmacology and Toxicology’s additional admission requirements stated below.

  • An appropriate bachelor’s degree from a recognized university with a final-year average of at least a B+.

  • Applicants are normally required to have taken courses in physiology and biochemistry, or applied sciences sufficient to form a foundation for their work in pharmacology.

  • At the discretion of the program director, applicants who demonstrate pharmacology knowledge that significantly overlaps with the Applied Clinical Pharmacology curriculum may be considered for advanced standing with either:

    • a bachelor’s degree specializing in pharmacology or biomedical toxicology or

    • MD degree (undergraduate medical education) with coursework in pharmacology.

Program Requirements

Coursework. Students must complete at least 4.0 full-course equivalents (FCEs) as follows:

  • PCL 1002Y Graduate Pharmacology (1.0 FCE)

  • PCL 1004Y Clinical Pharmacology (1.0 FCE)

  • PCL 1100H0 Applied Skills in Clinical Pharmacology (0.5 FCE)

  • PCL 2200Y0 Major Research Project (1.0 FCE), starting in the Fall of Year 1.

  • At least one half-course elective (0.5 FCE) chosen from the following list, and upon recommendation and approval by the program director:

    • PCL 1101H0 Technology, Techniques, and Translation in Pharmacology and Toxicology

    • PCL 1300H Selected Topics in Clinical Pharmacology and Toxicology (Credit/No Credit)

    • CHL 5201H Biostatistics I (exclusion: LMP 1407H)

    • JNP 1014Y Interdisciplinary Toxicology

    • JPM 1005Y Behavioural Pharmacology

  • Note: students participating in this advanced-standing option are not eligible to enrol in a practicum course.

Program Length

3 sessions (typical registration sequence: F/W/S)

Time Limit

​3 years

0 Course that may continue over a program. The course is graded when completed.

Pharmacology and Toxicology: Pharmacology PhD

Doctor of Philosophy

Program Description

The objective of the PhD degree is to have students possess a comprehensive understanding of the general area of pharmacology, in addition to specific expertise in their particular area of interest. They build on their knowledge of pharmacology so that they are able to think critically about specific areas in pharmacology. They should be able to formulate and design, as well as carry out and interpret investigations. Their findings should be publishable. They should show capacity for continuing significant contributions in pharmacology and for conducting independent research.

Applicants may enter the PhD program via one of three routes: 1) following completion of an appropriate master’s degree; 2) transfer from the University of Toronto MSc program; or 3) direct entry following completion of an appropriate bachelor’s degree.

PhD Program

Minimum Admission Requirements

  • Applicants are admitted under the General Regulations of the School of Graduate Studies. Applicants must also satisfy the Department of Pharmacology and Toxicology's additional admission requirements stated below.

  • Appropriate master's degree from a recognized university with an average of at least a B+ in master's degree courses.

  • Applicants are normally required to have taken courses in physiology, biochemistry, or applied sciences sufficient to form a foundation for their work in pharmacology.

  • The department determines the eligibility of prospective students. The department assesses the student's ability for advanced study and independent research in ph​armacology.

  • Students transferring from the master's program in Pharmacology to the PhD program may receive full credit for master's courses towards doctoral course requirements, with the department's permission.

  • Well-qualified students with excellent research potential holding an appropriate bachelor's degree from a recognized university may be considered for direct entry to the PhD program. These applicants must have achieved a minimum final-year average of A–.

  • Applicants admitted without prior screening (i.e., with MSc degrees from other departments or universities, and students admitted with a bachelor's degree) will have their research ability reviewed after completion of one year. Upon successful completion of a departmental seminar and recommendation from the student's advisory committee, the student will be permitted to proceed with the PhD program.

  • The department must be satisfied about the applicant's background, accomplishments, and financial support.

  • All successful applicants are responsible for obtaining research supervision and financial support before they are permitted to officially register in their program.

Program Requirements

  • Coursework. Students must complete 3.0 full-course equivalents (FCEs) as follows:

    • PCL 1002Y Graduate Pharmacology (primary subject)

    • PCL 1003Y0 Seminars in Pharmacology (Credit/No Credit)

    • 1.0 additional FCE (secondary subject)

    • Any other courses advised by the Graduate Education Committee. The student's advisory committee should help the student determine the secondary course.

  • Pharmacology graduate faculty members also offer a variety of laboratory-based and tutorial-based learning modules to provide breadth to the student's training experience beyond their particular areas of research focus. During their program, PhD students are required to choose four breadth modules from among available options. 0.5 FCE from outside the student's research area may substitute for one of the five breadth modules. The student's advisory committee will assist the student in choosing suitable modules.

  • As part of the course requirement for PCL 1003Y0Seminars in Pharmacology, the student must present thesis material in seminars to the department on two occasions, one of which will take place between two and six months prior to the departmental Final Oral Examination.

  • Each student will participate in a research program and present the results of the investigation as a written thesis. The thesis must be orally defended to the satisfaction of a thesis examination committee.

  • Minimum period of two full years of residence, during which time the student is required to be on campus full-time and consequently in such geographical proximity as to be able to participate fully in the department's activities associated with the program.

Program Length

4 years full-time; 5 years transfer-from-master's; 5 years direct-entry

Time Limit

6 years full-time; 7 years transfer-from-master's; 7 years direct-entry

0 Course that may continue over a program. The course is graded when completed.

Pharmacology and Toxicology: Pharmacology MSc, PhD Courses

The department should be consulted each session as to course offerings. Students may also find up-to-date course information on the departmental website.

PCL 1001Y
Systems Pharmacology
PCL 1002Y
Graduate Pharmacology
PCL 1003Y0
Seminars in Pharmacology (Credit/No Credit)
PCL 1004Y
Clinical Pharmacology
PCL 1100H0 Applied Skills in Clinical Pharmacology
PCL 1101H0
Technology, Techniques, and Translation in Pharmacology and Toxicology
PCL 1110H
Applied Skills in Clinical Pharmacology
PCL 1300H
Selected Topics in Clinical Pharmacology and Toxicology (Credit/No Credit)
PCL 1402H
Pharmacology and Toxicology in Drug Development
PCL 1491H
Clinical Pharmacology: Principles in Practice (co-requisite: PCL 1004Y or prior pharmacokinetics course)
PCL 2100Y0 (2.0 FCEs) Practicum in Clinical Pharmacology (Credit/No Credit) (prerequisite: PCL 1100H0)
PCL 2101Y0
Practicum in Clinical Pharmacology I (Credit/No Credit) (prerequisite: PCL 1100H0)
PCL 2102Y0
Practicum in Clinical Pharmacology II (Credit/No Credit) (prerequisite: PCL 1100H0)
PCL 2200Y0
Major Research Project (prerequisite or co-requisite: PCL 1100H0)
PCL 2201Y0
Research Project Extended Study (Credit/No Credit) (prerequisite: PCL 2200Y)
CHL 5201H Biostatistics I (exclusion: LMP 1407H)
JFK 1120H
Selected Topics in Drug Development I
JFK 1121H
Selected Topics in Drug Development II
JFK 1122H
Drug Transport Across Biological Membranes
JNP 1014Y
Interdisciplinary Toxicology
JNP 1016H
Graduate Seminar in Toxicology
JNP 1017H+
Current Topics in Molecular and Biochemical Toxicology
JNP 1018H+
Molecular and Biochemical Basis of Toxicology
JNR 1444Y
Fundamentals of Neuroscience: Cellular and Molecular
JPM 1005Y
Behavioural Pharmacology
JYG 1555H
Advanced Topics: Cellular and Molecular Neurobiology
LMP 1407H Introductory Biostatistics and Clinical Investigation (exclusion: CHL 5201H)

0 Course that may continue over a program. The course is graded when completed, or credit is given when the course is completed.

+ Extended course. For academic reasons, coursework is extended into session following academic session in which course is offered.